ਗੁਰੂ ਅੰਗਦ ਦੇਵ ਵੈਟਨਰੀ ਐਂਡ ਐਨੀਮਲ ਸਾਇੰਸਜ਼ ਯੂਨੀਵਰਸਿਟੀ
Guru Angad Dev Veterinary And Animal Sciences University

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College of Animal Biotechnology

Microbial & Environmental Biotechnology
  • Two vaccine constructs encoding canine Mammaglobin + Murine IL2 and Canine Mucin-1 + murine IL2 in pVAX-1 have been generated. The construct with canine mucin-1 + mice IL-2 showed mammary tumor regression in mice with enhanced CMI response.
  • Sandwich ELISA based on canine recombinant Hsp90B1, Mammaglobin, and MMP3 has been developed for the serodiagnosis of canine mammary tumors.
  • Recombinant HSP40 (DnaJ) and HSP70 (DnaK) of Brucella spp have been evaluated for their efficacy as immune modulators against Brucella-specific protein in mice. The proteins were found to stimulate CMI response to a greater extent.
  • A dedicated lab for the diagnosis of leptospirosis has been established under the DBT-CRCN project. More than 1000 serum samples have been tested using MAT to study the seroepidemiology of leptospirosis. Similarly about 230 samples have been tested with PCR. About 10 % seropositivity was observed in MAT and 2% positive samples were found in PCR.
  • The hsp15 gene of Leptospira interrogans was cloned and characterized. Also the Serum amyloid A gene from quails was cloned and sequenced for the first time and its expression against bacterial infections was studied.
  • A stable mammalian cell line expressing Japanese Encephalitis Virus Like Particles (JE-VLP) has been developed.
  • Sub-viral Particles (SVP) of the Japanese Encephalitis virus and Infectious Bursal Disease virus have been produced using a baculovirus expression system.
  • Development of Canine distemper virus rescue system
  • Development of sero-diagnostics for Canine distemper virus and African swine fever virus
  • Development of nucleic acid-based diagnostics for Canine distemper virus, African swine fever virus, Porcine parvovirus, Porcine circovirus etc.