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Gadvasu

ਗੁਰੂ ਅੰਗਦ ਦੇਵ ਵੈਟਨਰੀ ਐਂਡ ਐਨੀਮਲ ਸਾਇੰਸਜ਼ ਯੂਨੀਵਰਸਿਟੀ
Guru Angad Dev Veterinary And Animal Sciences University

ADMISSION 2019-20
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College of Veterinary Science

Veterinary Pathology
VETERINARY-PATHOLOGY
z

Sr. No.

Title of Project

Objectives

Investigators

Budget

In lacs

Sponsoring Agency

Duration of the Project

     1. 

Studies on Intra-vitam diagnostic approaches of rabies in animals

To study the Intra-vitam diagnostic approaches of rabies in animals

PI: Dr. C. K. Singh

 

9.175

UGC, New Delhi

 

2012-2015

       2.

Studies on lymphangiogenesis in canine model of human breast cancer

To study the expression of the lymphangiogenic markers in canine tumor.

 

PI: Dr. N. K. Sood

9.35

UGC, New Delhi

2012-15

       3.

Studies on epithelial-mesenchymal transition (EMT) in acute and chronic lung injury

a) To evaluate the light and ultrastructural changes in the lung.

b) To quantitate the expression of biomarkers of EMT in the lung.

c) To correlate the structural changes with EMT biomarkers expression.

d) Therapeutic approaches using anti-fibrotic herbal drugs, like baicalein/ Salvianolic acid B.

PI: Dr. N.D. Singh

21.60

SERB, DST, New Delhi

2015-2019

.      4.

Rapid and confirmatory detection of important animal meat based food borne pathogens and its associated toxicants and natural toxicants by using immuno-histopathological and molecular techniques- A step towards One Health Concept

1. Study on tissue specific distribution of various zoonotic pathogens/ antigen across thecarcass by employing immuno-pathological techniques (immunohistochemistry).

2. Development of species specific or genus specific oligonucleotide probes to validate the presence of already established infections in carcass by employing in-situ hybridization techniques (ISH).

3. Utilization of species specific primers and probes to detect the actual load of pathogens in various organs, besides determining the pathogen load specific induction of gross /microscopic lesion at various organs by employing real time quantitative PCR (RT-PCR) techniques. Additionally, this technique can be utilized in live animals by using

their collected blood samples.

4. Isolation of organisms in suspected mixed infections and characterization of closely related bio-transformation if any, by using PCR based restricted fragment length polymorphism (RFLP) techniques.

PI: Dr. H.S. Banga

Co PI: Drs. S. Deshmukh, R.S. Brar, N.D. Singh, APS Brar, P. Dwivedi and N. Mehta

 

43.0

MOFPI SERB (DST), New Delhi

2016-2019

       5.

Comprehending the role of mucosal associated immunity during pathogen interaction following Avibacterium paragallinarum infection in poultry (chicken and Japanese quail) for developing a futuristic mucosal vaccine

1. To understand route of invasion of Avibacterium paragallinarum and its interaction with various immune cells/tissue of hosts following primary contact.

2. To understand sequential and dynamic development of mucosa-associated immune response following an exposure to both live and inactivated/attenuated bacterium.

3. To compare immuno-pathogenetic mechanisms between different serovars in single host i.e. chickens to better understand the associated immunopathologic process and histopathological alteration.

4. To study comparative difference in immuno-pathological manifestation of infection between different hosts’s i.e. chicken and Japanese quail.

PI: Dr. S. Deshmukh

Co PI: Dr. H.S. Banga, Dr. Anish Thakur, Dr.R. S. Brar and Dr. S. Sodhi

 

29.50

DST, New Delhi

2016-2019

     6. 

Understanding in situ- dynamics of provincial innate immune response during reproductive salmonellosis in chicken for considering future practice of anal (cloacal) mucosal vaccination”

1. To study in-situ demonstration of bacterial uptake/entrance within chicken’s reproductive tract to assess its putative pan reproductive localization in uterus to evaluate maximum demographic zone/tissue specific tropism of bacterium (Salmonella organism).

2. To explore spatial distribution and in situ tissue expression of m RNA transcripts of some selective immune relevant genes, specific toll like receptors (TLR) and defensin molecules in female reproductive tract of chicken following infection with Salmonella organism (Poultry specific sero vars). Customized locked nucleic acid (LNA) probe will be utilized for this technique and in situ-hybridization technique will be developed and operated.

3. To demonstrate emergence of chicken specific dendritic cells population(s), macrophage(s) and other adaptive immune component and its possible anatomical localization within female reproductive tract (Formalin fixed paraffin embedded (FFPE) tissue) of chicken following Salmonella infection(s) (Poultry specific sero vars) through immunohistochemistry. The difference in the relative proportion of these important markers would help us in identifying immune component important in restricting infections and resolution of infections in protected   birds.

4.            To demonstrate action of localized secretory antibody response in mitigating the harmful influence of Salmonella infection at various regions of chicken’s reproductive tract.

PI: Dr. S. Deshmukh

Co PI: Drs. S. Sodhi, R. S. Brar and H S Banga 

35.079

DBT, New Delhi

2017-2020

.    7.  

Studies on patho-morphological alterations in blood cells to develop a foldscope based field test

Studies on patho-morphological alterations in blood cells to develop a foldscope based field test

PI: Dr. C.K.Singh

Co PI: Drs. Kuldip Gupta and Vishal Mahajan

 

6.0

DBT

2018-2019

     8. 

Immunopathological and molecular studies on bovine cryptosporidial diarrhea and associated etiologies

1. To diagnose C. parvum and associated etiological agents in field cases of bovine      calf diarrhea.

2. To compare the diagnostic efficacy of conventional, immunopathological and       molecular techniques in infectious bovine calf diarrhea.

PI: Dr. APS Brar

Co PI: Dr. B.S. Sandhu, Dr. Deepti Narang, Dr. C.K.Singh, Dr. Kuldip Gupta and Dr. N.K.Sood

24.67

SERB, New Delhi

2018-2022

       9.

A Centre of Advanced Faculty Training (CAFT) in the Department of Veterinary Pathology

To provide hands-on-training to the young scientists, faculty and researchers.

PI: Dr. C. K. Singh

Co PI: Dr. Kuldip Gupta

Dr. ND Singh

11.415

ICAR

2017 onwards

      10.

To strengthen the research facilities in the Department of Veterinary Pathology    under the (DST) FIST program

To strengthen the research facilities in the Department of Veterinary Pathology   

PI: Dr. C. K. Singh

Co PI: Dr. Kuldip Gupta and Dr. N.D. Singh

 

58.00

DST, New Delhi

2018 onwards