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Gadvasu

Guru Angad Dev Veterinary And Animal Sciences University
ਗੁਰੂ ਅੰਗਦ ਦੇਵ ਵੈਟਨਰੀ ਐਂਡ ਐਨੀਮਲ ਸਾਇੰਸਜ਼ ਯੂਨੀਵਰਸਿਟੀ

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College of Animal Biotechnology

Faculty Detail

Dr. Ratan Kumar Choudhary

Designation: Assistant Professor
Contact Address: Department of Bioinformatics, College of Animal Biotechnology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana-141004
Telephone :
Mobile: +918427405856
Email:ratan.choudhary@gadvasu.in, vetdrrkc@gmail.com

Academic Credentials

  • B.V.Sc. & A.H  (TANUVAS, Chennai, India)
  • M.V.Sc. (in AGB, IVRI, Bareilly India)
  • Ph.D. (in Animal and Avian Sciences, University of Maryland, College Park, USA)
  • Post-doctorate Fellow (University of Kentucky, Lexington, USA, 2011-2013)
  • Post-doctorate Associate (University of Vermont, Burlington, USA, 2018-2020)

Teaching and Other Appointments

Field of Specialization: Stem cell and Molecular biology, Bioinformatics

Teaching various UG and PG courses of College of Animal Biotechnology pertaining to Cell and Molecular Biology, Bioinformatics and Animal Biotechnology.

Other Appointments

  • Member, Academic Affair Committee (COABT)
  • Member, PME cell (COABT)
  • Member, IPR cell (COABT)

Area of Research Interests

Our laboratory, Animal Stem Cells lab, is working on two aspects of stem cell biology,

1) exploring strategies to increase milk production in dairy animals by increasing mammary stem cell population using nucleotide analog, to increase cell turnover and lactation persistency and

2) developing regenerative therapy in canines using mesenchymal stem cell and cell-derived products. One of the approaches that we are interested in is the in-situ amelioration of mammary stem/progenitor cells. We are attempting to establish the application of stem cells and cell-based products for therapeutic application in animal diseases namely, mastitis, and wound healing. Finding an alternative therapy of mastitis without the use of antimicrobials and enhancing tissue regeneration using cell-based therapy are our long-term goals of the research.


Ongoing Projects

SN

Name/ No of Project/ Scheme

Funding Agency

Period (from – to)

Total Funding

Role

1

Continue Biotechnology Education (CBE) lecture series 2021-22

IndiaAlliance DBT Wellcome

09/2021-09/2022

Rs. 0.42 lacs

Co-PI

2

Modelling of indigenous diagnostics and immunopotent vaccine candidates to combat African swine fever in India

DBT

25/03/2021- 25/03/2024

Rs. 39.56 lacs

Co-PI

3

Elucidating the role of Cas6, Cas7 and Cas8 in spirochetes CRISPR adaptive immunity against alien genetic elements

North-East Twinning Project, Department of Biotechnology (DBT), New Delhi

22/12/2017- 12/2021

Rs. 60.0 lacs

 

CC-PI

4

Parentage determination and cytogenetic profiling in dogs

DBT, New Delhi

27/03/2018 - 26/09/2021

39.83 Lakhs

Co-PI

5

Fast clotting clinical grade hemostatic agent for emergency care

IMPRINT-2, SERB-DST, New Delhi

10/2018- 02/07/2022

 

Co-PI

6

Xanthosine treatment: A novel strategy to increase milk production and mammary stem cells

Department of Biotechnology, Govt. of India, New Delhi

 

20/06/2014 to 20/12/2017

Rs. 67.0 lacs

 

 

 

PI

7

Gene expression and identification of functional status of buffalo mammary gland

Rastriya Krishi Vigyan Yojna (RKVY)- State funded

11/2014 to 11/2017

Rs. 15.0 lacs

PI


Research Honour’s /Awards

  • Guru Angad Dev Veterinary and Animal Sciences University “Appreciation Award for Research” for brining extra-mural funds for the basic research to the university – 2018.
  • Poster award at International Conference of Society for Bioinformatics and Biological Sciences (SBBS), SKAUST, Jammu, India; October 12-13.
  • Winner of Vector Lab’s (USA) photomicrography contest – 2017 (https://vectorlabs.com/uk/gallery/contest.html)
  • 2017 Poster Award at International Conference on Reproductive Health with Emphasis on Strategies for Infertility, Assisted Reproduction and Family Planning (ISSRF-2017), AIIMS, New Delhi, Jan 23-25 2017.
  • International Travel Award by DST, New Delhi – 2015
  • Second Prize Winner at BARC poster day at United States Department of Agriculture (USDA), Beltsville, Maryland- 2012
  • First Prize Winner PhD Division at the Joint Annual Meeting of the American Dairy Science Association (ADSA) and American Animal Science Association (ASAS) at New Orleans- 2011
  • Novus International Inc. Travel Award to 63rd Annual EAAP meeting at Bratislava, Slovakia– 2011
  • Second Prize Winner of Oral presentation, University of Maryland- 2011
  • Third Prize Winner at BARC poster day USDA, Beltsville-2011
  • R. F. Davis Scholarship for outstanding academic record, research and commitment to agriculture and natural resources, University of Maryland – 2011
  • Dean’s Fellowship, University of Maryland, College Park, Maryland – 2011
  • First Prize Winner of poster presentation, University of Maryland, College Park-2011
  • J. K. Goldhaber Travel Award, University of Maryland- 2010
  • Guru Angad Dev Veterinary and Animal Sciences University “Appreciation Award for Research” for brining extra-mural funds for the basic research to the university – 2018.
  • Poster award at International Conference of Society for Bioinformatics and Biological Sciences (SBBS), SKAUST, Jammu, India; October 12-13.
  • Winner of Vector Lab’s (USA) photomicrography contest – 2017 (https://vectorlabs.com/uk/gallery/contest.html)
  • 2017 Poster Award at International Conference on Reproductive Health with Emphasis on Strategies for Infertility, Assisted Reproduction and Family Planning (ISSRF-2017), AIIMS, New Delhi, Jan 23-25 2017.
  • International Travel Award by DST, New Delhi – 2015
  • Second Prize Winner at BARC poster day at United States Department of Agriculture (USDA), Beltsville, Maryland- 2012
  • First Prize Winner PhD Division at the Joint Annual Meeting of the American Dairy Science Association (ADSA) and American Animal Science Association (ASAS) at New Orleans- 2011
  • Novus International Inc. Travel Award to 63rd Annual EAAP meeting at Bratislava, Slovakia– 2011
  • Second Prize Winner of Oral presentation, University of Maryland- 2011
  • Third Prize Winner at BARC poster day USDA, Beltsville-2011
  • R. F. Davis Scholarship for outstanding academic record, research and commitment to agriculture and natural resources, University of Maryland – 2011
  • Dean’s Fellowship, University of Maryland, College Park, Maryland – 2011
  • First Prize Winner of poster presentation, University of Maryland, College Park-2011
  • J. K. Goldhaber Travel Award, University of Maryland- 2010

No. of Publications

Research: 45           Extension: 01    Books: 02        Manuals: 08        Book Chapters: 08


Publications

  • Sahoo B, Choudhary, R. K., Sharma P, Choudhary S and Gupta MK. 2021. Significance and Relevance of Spermatozoal RNAs to Male Fertility in Livestock. Front. Genet. 12:768196. doi: 10.3389/fgene.2021.768196. https://www.frontiersin.org/articles/10.3389/fgene.2021.768196/full     (IF-4.599).
  • Choudhary, R. K and   Zhao, F-Q. 2021. Invited Review: Stem cells in mammary health and milk production. Current Stem Cell Research & Therapy (under press). (IF-2.614)
  • Choudhary, R. K. and Capuco, A. V. 2021. Expression of NR5A2, NUP153, HNF4A, USP15 and FNDC3B is consistent with their use as novel biomarkers for mammary stem/progenitor cells. Mol Histol. https://doi.org/10.1007/s10735-020-09948-8. (IF-2.35).
  • Spitzer, A., Tian, Q., Choudhary, R. K. and Zhao, F-Q. 2020. Bacterial endotoxin induces oxidative stress and reduces milk protein expression and hypoxia in the mammary gland. Oxidative Medicine and Cellular Longevity. https://doi.org/10.1155/2020/3894309 (IF-4.868).
  • Shangraw, E., Rodrigues, R., Witzke, M., Linder, H. F., Choudhary, R. K., Spitzer, A., Zhao, F. -Q., McFadden, T. B. 2020. Intramammary lipopolysaccharide infusion elicits local or systemic effects depending on milk component. Journal of Dairy Science. https://doi.org/10.3168/jds.2019-18022 . (IF-3.082)
  • Capuco, A. V. and Choudhary, R. K. 2020. Invited Review: Determinants of milk production: Understanding population dynamics in the bovine mammary epithelium. J. Dairy Sci. 103(3):2928-2940. doi: https://doi.org/10.3168/jds.2019-17241 (IF-3.082)
  • Choudhary R. K., Shanti Choudhary, C. S. Mukhopadhyay, Devendra Pathak and Ramneek Verma. Deciphering the transcriptome of prepubertal buffalo mammary glands using RNA sequencing. 2019. Functional & Integrative Genomics. doi: 10.1007/s10142-018-0645-5 (IF-2.745)
  • Shanti Choudhary, Wenli Li, Derek Bickhart, Ramneek Verma, R. S. Sethi, C. S. Mukhopadhyay and Choudhary R. K. Examination of the xanthosine response on gene expression of mammary epithelial cells using RNA-seq technology. 2018. J. Anim Sci. Tech. https://www.ncbi.nlm.nih.  (IF-1.685)
  • Baldwin, VI, R. L., Capuco, A. V., Evock-Clover, C. M., Grossi, P., Choudhary, R. K., Elsasser, T. H., Bertoni, G., Trevisi, E., Harmon, R. J. and McLeod, K. L. 2016. Consumption of endophyte-infected fescue during the dry period increases milk production in the subsequent lactation. J. Dairy Sci. 99 (9): 7574 – 7589. (IF-3.082)
  • Choudhary, R. K. 2014. Mammary stem cells: Expansion and animal productivity. BMC J. Ani Sci Biotech. 5: 36. (IF-3.47)
  • Choudhary, R. K., and Capuco, A. V. 2012. In vitro expansion of mammary stem/progenitor cell population by xanthosine treatment. BMC Molecular and Cell Biology. 13:14. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407777/ (IF-3.73)
  • Choudhary, R. K., Li, R. W., Evock-Clover, C. M. and Capuco, A. V. 2013. Comparison of transcriptomes of long-term label-retaining-cells and control cells microdissected from mammary epithelium: An initial study to characterize potential stem/progenitor cells and identify possible biomarkers. Front. Oncol. 3 (21). (IF-4.25)