Gadvasu

Faculty Detail

Dr. Simrat Pal Singh Saini

Designation: Professor
Contact Address:Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana- 141 004
Telephone : 0161-2414032
Mobile: 9876198402
Email:spalsaini@yahoo.com

Academic Credentials

• B.V.Sc. & A.H.
• M.V.Sc.
• Ph. D.
• Post-doctoral Fellow University of  Pittsburgh, PA, USA

Teaching and Other Appointments

Other Appointments

• University NRI Advisor

Area of Research Interests

• Drug metabolism and pharmacokinetics (DMPK) in clinical cases
• Toxicology in animal disease models, involving multi-disciplinary, cross-functional teams

Ongoing Projects

Research Honour’s /Awards

• Post-doctoral Fellowship by University of Pittsburgh, Pittsburgh, PA.
• Limbach Entrepreneurial Center Scholarship by University of Pittsburgh, PA
• Young Scientist Award by Indian Society of Pharmacology and Toxicology, New Delhi. 
• Post-doctoral Fellowship by CSIR, New Delhi. 
• Senior Research Fellowship in Doctoral program by CSIR, New Delhi.
• University merit scholarship in Master’s program.
• State fellowship in Bachelor’s program. 
• University PIO (Public Information Officer)
• University Ombudsperson
• Incharge  IVSA ( International Veterinary Students Association)
• Member, IAEC (Institutional Animal Ethics Committee
  

No. of Publications

Publications

• Bhardwaj P, Sidhu PK, Saini SPS, M B D, Rampal S. 2019. Pharmacokinetic-pharmacodynamic relationship of marbofloxacin for Escherichia coli and Pasturella multocida following repeated intramuscular administration in goats. J Vet Pharmacol Ther.Jul;42(4):430-439. doi: 10.1111/jvp.12776. Epub 2019 May 7.PMID: 31102281
• Xie W, Uppal H, Saini SP, Mu Y, Little JM, Radominska-Pandya A, Zemaitis MA. 2004 Orphan nuclear receptor-mediated xenobiotic regulation in drug metabolism. Drug Discov Today.May 15;9(10):442-9. doi: 10.1016/S1359-6446(04)03061-2.PMID: 15109949 Review. 
  
• Singh NK, Saini SPS, Singh H, Jyoti, Sharma SK, Rath SS 2017 In vitro assessment of the acaricidal activity of Piper longum, Piper nigrum, and Zingiber officinale extracts against Hyalomma anatolicum ticks. .Exp Appl Acarol.Mar;71(3):303-317. doi: 10.1007/s10493-017-0113-2. Epub 2017 Mar 1.PMID: 28251408
• Saini SP, Zhang B, Niu Y, Jiang M, Gao J, Zhai Y, Hoon Lee J, Uppal H, Tian H, Tortorici MA, Poloyac SM, Qin W, Venkataramanan R, Xie W. 2011Hepatology Activation of liver X receptor increases acetaminophen clearance and prevents its toxicity in mice.. Dec;54(6):2208-17. doi: 10.1002/hep.24646.PMID: 21898498 
• Gaur A, Saini SP, Garg SK, Chaudhary RK, Srivastava AK. 2004 Pharmacokinetics of ofloxacin after a single intravenous bolus dose in neonatal calves. J Vet Pharmacol Ther. Apr;27(2):115-7. doi: 10.1111/j.1365-2885.2004.00493.x.PMID: 15096110 
• Uppal H, Saini SP, Moschetta A, Mu Y, Zhou J, Gong H, Zhai Y, Ren S, Michalopoulos GK, Mangelsdorf DJ, Xie W. 2007  Activation of LXRs prevents bile acid toxicity and cholestasis in female mice. Hepatology.Feb;45(2):422-32. doi: 10.1002/hep.21494.PMID: 17256725
• Saini SP, Sonoda J, Xu L, Toma D, Uppal H, Mu Y, Ren S, Moore DD, Evans RM, Xie W. 2004 A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification. Mol Pharmacol.Feb;65(2):292-300. doi: 10.1124/mol.65.2.292.PMID: 14742670
• Saini SP, Mu Y, Gong H, Toma D, Uppal H, Ren S, Li S, Poloyac SM, Xie W.. 2005 Dual role of orphan nuclear receptor pregnane X receptor in bilirubin detoxification in mice. Hepatology. Mar;41(3):497-505. doi: 10.1002/hep.20570.PMID: 15726644
• Uppal H, Toma D, Saini SP, Ren S, Jones TJ, Xie W. 2005 Combined loss of orphan receptors PXR and CAR heightens sensitivity to toxic bile acids in mice. Hepatology.Jan;41(1):168-76. doi: 10.1002/hep.20512.PMID: 15619241
  
• Mu Y, Stephenson CR, Kendall C, Saini SP, Toma D, Ren S, Cai H, Strom SC, Day BW, Wipf P, Xie W. 2005 A pregnane X receptor agonist with unique species-dependent stereoselectivity and its implications in drug development. Mol Pharmacol. Aug;68(2):403-13. doi: 10.1124/mol.105.013292. Epub 2005 May .PMID: 15872116
• Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor. Xie W, Yeuh MF, Radominska-Pandya A, Saini SP, Negishi Y, Bottroff BS, Cabrera GY, Tukey RH, Evans RM. 2003 Proc Natl Acad Sci U S A. Apr 1;100(7):4150-5. doi: 10.1073/pnas.0438010100. Epub 2003 Mar 18.PMID: 12644700 
• Gong H, Singh SV, Singh SP, Mu Y, Lee JH, Saini SP, Toma D, Ren S, Kagan VE, Day BW, Zimniak P, Xie W. 2006 Orphan nuclear receptor pregnane X receptor sensitizes oxidative stress responses in transgenic mice and cancerous cells. Mol Endocrinol. Feb;20(2):279-90. doi: 10.1210/me.2005-0205. Epub 2005 Sep 29.PMID: 16195250
• Gaur A, Garg SK, Saini SP. 2005 Comparative disposition kinetics of ofloxacin following a single i.m. and s.c. administration in neonatal calves. J Vet Pharmacol Ther.Oct;28(5):485-8. doi: 10.1111/j.1365 -2885. 00687.x.PMID: 16207313
• Saini SP, Srivastava AK. 2001 The disposition kinetics, urinary excretion and dosage regimen of ciprofloxacin in buffalo calves (Bubalus bubalis). Vet Res Commun. Dec;25(8):641-9. doi: 10.1023/a:1012791113342.PMID: 11767010
  
• Saini SP, Srivastava AK. The disposition kinetics, urinary excretion and dosage regimen of amikacin in cross-bred bovine calves. Vet Res Commun. 1998 Jan;22(1):59-65. doi:10.1023/a:1005987212046.PMID: 954199