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Gadvasu

Guru Angad Dev Veterinary And Animal Sciences University
ਗੁਰੂ ਅੰਗਦ ਦੇਵ ਵੈਟਨਰੀ ਐਂਡ ਐਨੀਮਲ ਸਾਇੰਸਜ਼ ਯੂਨੀਵਰਸਿਟੀ

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College of Animal Biotechnology

Microbial & Environmental Biotechnology
MICROBIAL-ENVIRONMENTAL-BIOTECHNOLOGY

S. no.

Title of the project

Objectives

Investigators

Budget

 

Funding agency

Duration of Project

1.       

Development and Evaluation of Therapeutic Xenogenic DNA Vaccines Based on Canine Homologous Marker Sequences against Mammary Tumors in Mice Models.

1. Heterologous expression of canine mammary tumor specific/ associated markers in prokaryotic /eukaryotic system.

2. Generation of bi-cistronic recombinant plasmids (eukaryotic expression vectors) expressing these genes along with IL-2.

3. Evaluation of efficacy of these therapeutic xenogenic DNA vaccines against induced mammary tumors in mice models.

PI: Dr. B.V. Sunil Kumar

Co-PI:

Dr. Ramneek

Dr. J.S. Arora

Dr. Kuldip Gupta

Dr. Ashwani Kumar

Rs. 30.0 lakhs

DBT, India

2018-2021

2.       

Establishment of a laboratory for diagnosis of leptospirosis

1. Development of a laboratory committed for diagnosis of leptospirosis.

2. To ascertain the current status of leptospirosis in northern India.

 

PI: Dr. Satparkash Singh

Co-PI:

Dr. Simranpreet Kaur

Dr. Randhir Singh

Dr. ST Singh

Dr. Dipak Deka

Dr. A.K. Arora

Rs. 48.432 lakhs

DBT, India

2018-2021

3.       

Development of user-friendly diagnostic kit for Marek’s disease.

1. Development and evaluation of recombinant gE protein based indirect ELISA for detection of antibodies against MDV infection

PI: Dr NK Singh

Co-PI: NA

Rs. 6.91 Lakhs

UGC, India

2014-2018

4.       

Development of sub-viral particles of Infectious Bursal Disease virus as a potential vaccine and diagnostic candidate.

1. To construct recombinant baculovirus having VPX and/or VP2 of Infectious Bursal Disease Virus (IBDV)

2. To generate subviral particles of IBDV in insect cell line (Sf-9)

PI: Dr NK Singh

Co-PI:

Dr. Dipak Deka

Dr. Ramneek

Rs. 26.35 Lakhs

DBT, India

2014-2018

5.       

Development of subviral particle of Japanese encephalitis virus (JEV) as a candidate vaccine against JEV.

1. To generate subviral particles of IBDV in insect cell line (Sf-9)

2. To generate subviral particles of JEV in insect cell line (Sf-9)

3. To evaluate the subviral particles as a vaccine candidate

PI: Dr NK Singh

Co-PI:

Dr Dipak Deka

Rs. 16.4 Lakhs

DAE, India

2014-2018

6.       

Studies on Cloning and Expression of Heat Shock Proteins (Hsps) of Brucella spp. and their Immunological Characterization in Experimental animals

1. Cloning and heterologous expression of Heat Shock Protein (dnaK and dnaJ) genes of Brucella spp.

2. Immunological characterization of the expressed proteins in experimental animal model.

PI: Dr. B.V. Sunil Kumar

Co-PI: NA

14.158 Lakh

UGC, India

2014-2017

7.       

Development and Evaluation of Sero-diagnostic Assay for Timely Diagnosis and Prognosis of Mammary Tumors.

1. To study expression profile of Mammaglobin, HSP90 and ErbB genes in normal and mammary tumor cases by qPCR (with dog as model animal).

2. To clone and express candidate biomarkers (mammaglobin, HSP90 and ErbB) in heterologous expression system.

3. To develop hyperimmune antisera against the expressed proteins in suitable laboratory animals and to develop sandwich ELISA for diagnosis and prognosis of mammary tumors.

PI: Dr. B.V. Sunil Kumar

Co-PI:

Dr. Ravikant Agrawal

Dr. Dipak Deka

19.90 Lakh.

DBT, India

2013-2017

8.       

Development of virus-like particle (VLP) of Japanese encephalitis virus as a potential vaccine candidate

1. To construct recombinant lentiviral vector having pre-membrane (prM) and envelope (E) genes of Japanese encephalitis virus (JEV)

2. To generate permanently transduced BHK-21 cell line for constitutive expression of VLP

3. To evaluate the VLP as a vaccine candidate

PI: Dr NK Singh

Co-PI:

Dr. Dipak Deka

Dr. Ramneek

Dr. PK Gupta

38.276 Lakh

DBT, India

2013-2017