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Gadvasu

Guru Angad Dev Veterinary And Animal Sciences University
ਗੁਰੂ ਅੰਗਦ ਦੇਵ ਵੈਟਨਰੀ ਐਂਡ ਐਨੀਮਲ ਸਾਇੰਸਜ਼ ਯੂਨੀਵਰਸਿਟੀ

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College of Veterinary Science

VETERINARY-PHARMACOLOGY---TOXICOLOGY
VETERINARY-PHARMACOLOGY---TOXICOLOGY

Research Projects (Extramural):

Name of P.I and Co-I& others Title of the Project Funding Agency Research Highlights (not more than 50 words in bullet form) Year
PI- Dr. S. K. Sharma

CoPIs-

Dr. V. K. Dumka

Dr. S. Rampal
Pharmacokinetics-pharmacodynamics integration and toxicological studies of fluoroquinolones and cephalosporins in buffalo species: CSIR The pharmacokinetic properties and urinary excretion of cefquinome, were investigated in healthy, febrile and hepatic dysfunctioned buffalo calves (2 mg/kg body weight).

plasma conc. in febrile and hepatic dysfunctioned animals were higher. The drug more extensively distributed to various body fluids and tissues of febrile and hepatic dysfunctioned animals than healthy animals.

Cefquinome at the dose rate of 2 mg/kg for 7 days did not produce any significant effect on biochemical and haematological parameters. A dose of 2 mg/kg can be repeated at 24 hours interval without any adverse effects.
2010-2013
PI- Dr. V. K. Dumka
CoPIs-
Dr. S. Rampal
Influence of Exposure to New Generation Insecticides on the Disposition of Antimicrobial Agents: UGC Flubendiamide toxicity was associated with neurotoxic effects, hepatic and renal damage, oxidative stress, adverse effects on thyroid hormone function and change in blood mineral profile of buffalo calves.
·Favourable pharmacokinetic profile of lincomycin suggested it to be an appropriate antibacterial in buffalo species for gram positive and anaerobic bacterial ineections.

Oral subchronic toxicity of quinalphos led to oxidative stress, hepatic, renal and muscle injury along with significant inhibition of erythrocytic and plasma cholinesterase enzyme.

lincomycin at a dose of 10 mg/kg body weight at 12 h interval would be sufficient both under healthy and insecticide-exposed condition to maintain T>MIC above 60% following IV injection for bacteria with MIC values £ 1.6 µg/ml. · Oral subchronic toxicity of quinalphos altered the PK of lincomycin in buffalo calves.

2011-2014
PI- Dr S. Rampal. CoPIs-
Dr. Rajdeep Kaur
Evaluation of retinopathic potential of fluoroquinolones UGC The effect of repeated administration of gatifloxacin (10 mg/kg and 20 mg/kg for 21 days) on the antioxidant status and its potential to induce retinal damage was studied in rabbits.

There was marked alteration in antioxidant status increase in lipid peroxidation and activities of the antioxidant enzymes GPx and catalase and decrease in SOD and blood glutathione.

Histopathological examination of the tunics of eyeball revealed clumping of outer layer of nuclei at high dose indicating that gatifloxacin has mild effect on structural integrity of retina.
2011-2013
PI- Dr. Rajdeep Kaur CoPIs-
Dr. S. Rampal
Toxicokinetics of pyrethroids: UGC OOral subacute and subchronic toxicity studies of fenvalerate in buffalo calves showed marked changes in the antioxidant profile, biochemical and haematological status of buffalo calves. However, they failed to elicit any significant effect on TSH levels, but produced significant decline in T4 levels. There were significant alterations in the toxicokinetics of this compound following repeated oral administration.

Oral subacute toxicity study of bifenthrin in buffalo calves produced mild degree of toxic signs and significantly disturbed the antioxidant homeostasis of the exposed animals. In addition, there were characteristic changes in the biochemical and haematological parameters.
2013-2016
PI- Dr. S P s saini CoPIs-
Dr. S. Rampal
Dr. S. K. Sharma
Ameliorative measures for enrofloxacin-induced testicular toxicity in rats Standardization of procedures for study of following biochemical parameters viz. blood glutathione, lipid peroxidation, glutathione peroxidase, glutathione reductase, glutathione-S-transferase, superoxide dismutase, catalase, G-6-P-dehydrogenase and hemoglobin has been done.

Pilot experiments to compute suitable oral dose of enrofloxacin in rats were done. The dose of enrofloxacin was computed to be 80 mg/kg P/O.

Standardization of histopathological technique for testes and sperm morphology are also being undertaken.
2014-2017